Osteopontin in cyclosporine toxicity
نویسندگان
چکیده
منابع مشابه
Osteopontin expression in human cyclosporine toxicity.
BACKGROUND Osteopontin is a secreted phosphoprotein that has a number of diverse biological functions, including cell signaling, mediation of cell adhesion, migration, and chemoattraction of monocytes/macrophages. Up-regulation of osteopontin expression by proximal tubular epithelium has been demonstrated in both human and rodent models of renal injury in association with macrophage influx. M...
متن کاملDelusions and cyclosporine toxicity.
examination unremarkable except for some skin changes in the previously irradiated area. Chest x ray and bone scan were normal. Myelography revealed minor posterior pro-trusion of L5/S1 disc on flexion of the back. Cerebrospinal fluid contained normal cellular constituents but elevated protein at 0-8 g/litre. Motor conduction velocities in left posterior tibial and both lateral popliteal nerves...
متن کاملPathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin.
Low-salt-diet, cyclosporine (CsA; 15 mg/kg per day)-treated rats develop striped interstitial fibrosis, arteriolar hyalinosis, and azotemia similar to the chronic nephropathy observed in humans. To examine the role of angiotensin II in this model, rats on a low-salt diet were given CsA, CsA and the angiotensin II receptor Type I antagonist Losartan (10 mg/kg per day), CsA and hydralazine/furose...
متن کاملPathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer.
Osteopontin (OPN) is a highly modified integrin-binding extracellular matrix glycophosphoprotein produced by cells of the immune system, epithelial tissue, smooth muscle cells, osteoblasts, and tumor cells. Extensive research has elucidated the pivotal role of OPN in cell signaling that controls inflammation, tumor progression, and metastasis. OPN interaction with the integrin receptors express...
متن کاملCyclosporine A toxicity in association with reduced renal mass.
The long-term effect of cyclosporine A (CsA) in male Wistar rats with reduced renal mass was studied. The aim of the study was to highlight the relationship of CsA effect on rats, simulating patients with two functioning kidneys (eg, heart, liver transplant recipients) and one kidney (renal transplant recipients). The Wistar rats were subjected to unilateral nephrectomy (Unx, n = 14) and to 5/6...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 2002
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2002.00440.x